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3.1.2 Type B (commercially used botanical drugs) Swertia chirayita (Family: Gentianaceae): Harvested from Uttarakhand, India (GPS coordinates: N3015, E7901) in October 2022

Psilocybin and psilocin regulate microglial immunomodulation and support neuroplasticity via serotonergic and AhR signaling

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Exogenous supplementation with this bacterium reduced urinary protein, blood urea nitrogen, and creatinine levels in DKD mice, decreased plasma levels of uremic toxins including TMAO, p-cresyl sulfate, and indoxyl sulfate, and protected intestinal mucosal barrier integrity through upregulation of MUC2, occludin, and ZO-1 protein expression [Animal model evidence only]

Tryptophan is primarily absorbed in the gut and metabolized by the gut microbiota through three downstream pathways: the 5-HT pathway, the kynurenine pathway, and the indole pathway (214)