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This article has supplemental material available at jpet.aspetjournals.org

This receptor specifically interacts with GLP-1, a key hormone that plays an integral role in regulating blood glucose levels, lipid metabolism, and several other crucial biological functions

Most of the research regarding coffee enemas derives from case reports, which typically highlight the risks of the procedure

The published human trials from the 1980s used 25 nmol/kg intravenously for short courses, typically four to seven nights, in chronic-insomniac volunteers