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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

In brain there was significant difference in dose and duration groups and in interaction between dose and duration groups of gene expression of brain aromatase and GnRh where F-value is greator than F-critical value (Table 9)

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